The Wegovy label includes a specific warning about acute kidney injury. The warning is tied to severe GI reactions (vomiting, diarrhea) and the loss of body fluid that follows them.

Severe nausea drops fluid intake; severe diarrhea increases fluid loss; the kidneys respond to the resulting drop in blood volume. The labeled warning centers on acute kidney injury due to volume depletion. The chain is GI side effects → dehydration → kidney stress.

The label points to renal-function monitoring when patients report adverse reactions that could lead to volume depletion. Closer attention during severe vomiting or diarrhea is the practical protection.